The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Neuromodulation of neuronal circuits: back to the future. Neuropeptide transmission in brain circuits.
These findings support a model in which peptidergic signaling within the dLS modulates dorsal hippocampal output and supports memory encoding. At the functional level, our data reveal a role for MCH signaling in the dLS in facilitating spatial memory. We found that MCH synchronizes dLS neuronal firing with its dCA3 inputs by enhancing GABA release, which subsequently reduces the FFI and augments dCA3 excitatory input strength, both via pre-synaptic mechanisms. Firing activity within the dLS in response to dorsal CA3 (dCA3) excitation is limited by strong feed-forward inhibition (FFI). In this study, in mice, we uncovered the physiological mechanism underlying the functional role of MCH signaling in projections to the dorsolateral septum (dLS), a region involved in routing hippocampal firing rhythms and encoding spatial memory based on such rhythms. Hypothalamic melanin-concentrating hormone (MCH) polypeptide contributes to regulating energy homeostasis, sleep and memory, although the mechanistic bases of its effects are unknown.
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